Chemical Name: 20,24R-Epoxy-9,19-cyclolanostane-3ß,6alpha,25-tetrol
Telomerase activator / Senolytic agent
Molecular Weight:
490.73
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[84605-18-5]
Formula:
C30H50O5
Application Notes:
Cycloastragenol is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8+ T lymphocytes from HIV-infected donors it retarded telomere shortening, increased proliferative potential and enhanced cytokine/chemokine production and antiviral activity.1 It suppressed lung damage in a idiopathic pulmonary fibrosis mouse model.2 It has also been shown to be a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mice with irradiation-induced aging.3
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