Chemical Name: 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one, 2',7-Dihydroxy-3,4-benzocoumarin
Mitophagy inducer
Molecular Weight:
228.20
Purity:
>98% by HPLC NMR (Conforms)
Form:
Pale-yellow solid
CAS Number:
[1143-70-0]
Formula:
C13H8O4
Application Notes:
Microbial metabolite of dietary ellagitannins produced in the gut.1 It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents.2 It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinsons disease model.3 The pro-mitophagy activity of UA may be beneficial in Alzheimers disease.4 Ex vivo UA-treated T cells display improved anti-tumor function.5
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