Chemical Name: (Z)-Pregna-4,17(20)-diene-3,16-dione
FXR antagonist
Molecular Weight:
312.45
Purity:
98% by TLC, NMR (Conforms)
Form:
Off-white solid
CAS Number:
[39025-23-5]
Formula:
C21H28O2
Application Notes:
A natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1 Attenuates astrocyte-mediated neuroinflam-mation.2 Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4
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