MRTX849, CAS [[2326521-71-3]]

Product Overview

• Article Name: MRTX849, CAS [[2326521-71-3]]
• Biozol Catalog Number: FBM-10-3928
• Supplier Catalog Number: 10-3928
• Alternative Catalog Number: FBM-10-3928-5MG, FBM-10-3928-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-[(2S)-4-[7-(8-Chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile. Alternate Names: Adagrasib

Product Description

Covalent KRASG12C inhibitor

Product Properties

• Molecular Weight: 604.13
• Purity: >98% by HPLC , NMR (Conforms)
• Form: White solid
• CAS Number: [2326521-71-3]
• Formula: C32H35ClFN7O2

Application Notes

• Application Notes: MRTX849 is a potent (IC50s = 14 nM NCI-H358, 5 nM MIA PaCa-2) and selective (over 463 proteins 1 µM) covalent KRASG12C inhibitor.1 It showed pronounced tumor regression in 17 of 26 KRASG12C-positive cell lines and xenograft models from multiple tumor types.2 MTRTX849 reversed the immunosuppressive tumor environment in a genetically modified mouse model and sensitized tumors to checkpoint inhibitor therapy in a genetically modified mouse KRASG12C lung adenocarcinoma model.3 It reversed ABCB1-mediated multidrug resistance in vitro and in vivo via attenuating ABCB1 efflux in drug-resistant cancer cells.4