Chemical Name: 1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione trifluoroacetate
Molecular glue handle
Molecular Weight:
388.34
Purity:
>98% by HPLC , NMR (Conforms)
Form:
Pale yellow solid
CAS Number:
[2913587-31-0]
Formula:
C15H18N2O3C2HF3O2
Application Notes:
JP-2-196 is a unique molecular glue chemical handle that binds several RING E3 ligases including RNF126, RNF40, MID2, RNF219, RNF14, and LRSAM1. Has been shown to induce proteasomal degradation of a wide variety of proteins when linked to the appropriate ligand.
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