Chemical Name: Methyl (1R,3S)-2-acryloyl)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Cysteine-reactive T cell activation suppressor
Molecular Weight:
404.42
Purity:
>98% by HPLC , NMR (Conforms)
Form:
White to off-white solid
Formula:
C23H20N2O5
Application Notes:
EV-96 is a cysteine-reactive immunosuppressive agent that suppresses T cell activation (EC50 <2.5 µM) via inhibition of NF-kB activation and degradation of key immune-relevant proteins including ITK, TEC, and CYTIP.1 EV-96 suppresses T cell activation by inhibiting the splicing factor SF3B1.2
* VAT and and shipping costs not included. Errors and price changes excepted
