RMC-7977, CAS [[2765082-12-8]]

Product Overview

• Article Name: RMC-7977, CAS [[2765082-12-8]]
• Biozol Catalog Number: FBM-10-3954
• Supplier Catalog Number: 10-3954
• Alternative Catalog Number: FBM-10-3954-1MG, FBM-10-3954-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (1R,5S)-N-[(7S,13S)-20-[5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl]-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetrazapentacyclo[17.5.2.12,5.19,13.022,26]octacosa-1(25),2,5(28),19,22(26),23-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide

Product Description

KRAS inhibitor

Product Properties

• Molecular Weight: 865.11
• Purity: >98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [2765082-12-8]
• Formula: C47H60N8O6S

Application Notes

• Application Notes: RMC-7977 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1