Chemical Name: 1-[2-[(4-Chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate. Alternate Names: 1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
Antifungal/Prevents cancer stem cell formation
Molecular Weight:
460.75
Purity:
>98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[61318-91-0]
Formula:
C18H15Cl3N2SHNO3
Application Notes:
Broad-spectrum imidazole antifungal used for the treatment of various skin infections. It inhibits the cytochrome P450 isozyme, C-14-alpha demethylase, preventing ergosterol synthesis. Sulconazole inhibited mammosphere formation, reduced NF-kB, and reduced extracellular IL-8 formation in breast cancer cells leading to inhibition of cancer stem cell formation.1 It has a similar effect on glioma stem cells.2
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