Brequinar sodium, CAS [[96201-88-6]]

Product Overview

• Article Name: Brequinar sodium, CAS [[96201-88-6]]
• Biozol Catalog Number: FBM-10-3965
• Supplier Catalog Number: 10-3965
• Alternative Catalog Number: FBM-10-3965-10MG, FBM-10-3965-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-Fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid sodium salt. Alternate Names: DuP-785, NSC 368390

Product Description

Dihysroorotate dehydrogenase inhibitor, antiviral

Product Properties

• Molecular Weight: 397.35
• Purity: 99% by HPLC NMR Conforms
• Form: White to off-white solid
• CAS Number: [96201-88-6]
• Formula: C23H14F2NO2Na

Application Notes

• Application Notes: Brequinar sodium is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50s between 0.2 and 5.8 µM in various cell lines3 and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4 Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5,6,7