Compound 147, CAS [[393121-74-9]]

Product Overview

• Article Name: Compound 147, CAS [[393121-74-9]]
• Biozol Catalog Number: FBM-10-3973
• Supplier Catalog Number: 10-3973
• Alternative Catalog Number: FBM-10-3973-10MG, FBM-10-3973-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide. Alternate Names: AA147

Product Description

ER stress sensing protein ATF6 activator

Product Properties

• Molecular Weight: 255.32
• Purity: 98% by HPLC , NMR (Conforms)
• Form: Beige to pale orange solid
• CAS Number: [393121-74-9]
• Formula: C16H17NO2

Application Notes

• Application Notes: Preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2 AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3 It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974.