DMB, CAS [[281209-71-0]]

Product Overview

• Article Name: DMB, CAS [[281209-71-0]]
• Biozol Catalog Number: FBM-10-3975
• Supplier Catalog Number: 10-3975
• Alternative Catalog Number: FBM-10-3975-5MG, FBM-10-3975-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-tert-Butyl-6,7-dichloro-3-methylsulfonylquinoxalin-2-amine. Alternate Names: 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

Product Description

Gasdermin D agonist/GLP-1 agonist

Product Properties

• Molecular Weight: 348.20
• Purity: 98% by HPLC , NMR (Conforms)
• Form: Yellow solid
• CAS Number: [281209-71-0]
• Formula: C13H15Cl2N3O2S

Application Notes

• Application Notes: DMB is a small molecule glucagon-like peptide 1 (GLP-1) ago-allosteric modulator and agonist (EC50 = 101 nM).1 It significantly stimulated insulin secretion in BRIN-BD11 cells and decreased overall glucose excursion in mice.2 DMB is a direct and selective gasdermin D (GSDMD) agonist that activates GSDMD pore formation and pyroptosis without cleaving GSDMD (EC50 = 700 nM).3 It induced pyroptosis in mouse cancer cell lines and induced tumor regression and enhanced antitumor immunity. DMB-treated tumor cells acted as a tumor vaccine in mice indicating that DMB can trigger immunogenic cell death that provides protective antitumor immunity.