ATX968, CAS [[2973395-71-8]]

Product Overview

• Article Name: ATX968, CAS [[2973395-71-8]]
• Biozol Catalog Number: FBM-10-3979
• Supplier Catalog Number: 10-3979
• Alternative Catalog Number: FBM-10-3979-5MG, FBM-10-3979-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[3-Chloro-5-(methanesulfonamido)phenyl]-4-(3-methylpyridin-2-yl)thiophene-2-carboxamide

Product Description

DHX9 inhibitor

Product Properties

• Molecular Weight: 421.91
• Purity: >98% by HPLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [2973395-71-8]
• Formula: C18H16ClN3O3S2

Application Notes

• Application Notes: ATX968 is a potent (EC50s: 3 nM ATPase, 60 nM circBRIP1), selective, and orally bioavailable inhibitor of DExH-box helicase 9 (DHX9, RNA helicase A), an important regulator of transcription, translation, and genomic stability.1 ATX968 selectively kills microsatellite instable colorectal cancer cells with deficient mismatch repair, but not microsatellite stable cells with proficient mismatch repair.2 Active in mouse xenograft (LS411N and SW480) models of microsatellite instable colorectal cancer.