ANP-230, CAS [[1233231-30-5]]

Product Overview

• Article Name: ANP-230, CAS [[1233231-30-5]]
• Biozol Catalog Number: FBM-10-3991
• Supplier Catalog Number: 10-3991
• Alternative Catalog Number: FBM-10-3991-5MG, FBM-10-3991-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2S)-2-[[3-Cyclobutyl-5-(3,4,5-trifluorophenoxy)imidazo[4,5-b]pyridin-2-yl]methylamino]propanamide. Alternate Names: DSP-2230

Product Description

Nav1.7, 1.8, 1.9 blocker

Product Properties

• Molecular Weight: 419.41
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1233231-30-5]
• Formula: C20H20F3N5O2

Application Notes

• Application Notes: ANP-230 is a state-independent selective inhibitor of sodium channels Nav1.7, 1.8, and 1.9 (IC50s respectively: 7.1 µM, 11.4 µM, and 6.7 µM).1 Selective over the cardiac Nav1.5 channel (IC50 = 156 µm). It potently reduced neuronal excitability in rat DRG neurons.3 ANP-230 reduced pain sensitivity in a mouse episodic pain syndrome model.2 It demonstrated efficacy in several models of neuropathic and inflammatory pain with no motor function impairment.3 It also potentiated the anti-allodynic effects of pregabalin and morphine when administered concurrently.3