Chemical Name: ((Z)-N,N-Dimethyl-9-[3-(4-methyl-1-iperazinyl)propylidene]thioxanthene-2-sulfonamide
Efferocytosis stimulator / Typical antipsychotic
Molecular Weight:
443.62
Purity:
>98% by HPLC, NMR (Conforms)
Form:
White solid
CAS Number:
[3313-26-6]
Formula:
C23H29N3O2S2
Application Notes:
Thiothixene is a clinically useful typical antipsychotic.1 It acts as an antagonist at multiple receptors including dopamine D2 and D3 (sub-nanomolar), histamine H1, serotonin 5-HT7, and alpha1/2-adrenergic. Thiothixene stimulates efferocytosis, the phagocytic removal of apoptotic cells by macrophages, via increased expression of the retinol-binding protein receptor Stra6L leading to arginase 1 production.2 A potential new use for an old drug to facilitate the removal of diseased tissue.
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