E3330, CAS [[136164-66-4]]

Product Overview

• Article Name: E3330, CAS [[136164-66-4]]
• Biozol Catalog Number: FBM-10-4000
• Supplier Catalog Number: 10-4000
• Alternative Catalog Number: FBM-10-4000-5MG, FBM-10-4000-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid. Alternate Names: (2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2-propenoic acid

Product Description

APE1 inhibitor/ferroptosis inducer

Product Properties

• Molecular Weight: 378.47
• Purity: >98% by HPLC, NMR (Conforms)
• Form: Orange solid
• CAS Number: [136164-66-4]
• Formula: C21H30O6

Application Notes

• Application Notes: E3330 is a hepatoprotective benzoquinone that inhibits TNF-alpha release via decreasing NFkB activation.1,2 It also is an inhibitor of AP endonuclease 1 (APE1) redox function.3 E3330 acts synergistically with cisplatin to increase cytotoxicity and impair cell migration and invasion in non-small cell lung cancer.4 Inhibition of APE1 with E3330 induces ferroptosis via impairment of AKT phosphorylation ultimately leading to Nrf2 degradation.5 It sensitizes osteosarcoma cells to ionizing radiation via ferroptosis induction.6