CPI-455, CAS [[1628208-23-0]]

Product Overview

• Article Name: CPI-455, CAS [[1628208-23-0]]
• Biozol Catalog Number: FBM-10-4035
• Supplier Catalog Number: 10-4035
• Alternative Catalog Number: FBM-10-4035-5MG, FBM-10-4035-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Product Description

Lysine demethylase KDM5 inhibitor

Product Properties

• Molecular Weight: 278.32
• Purity: 98% by HPLC NMR (conforms)
• Form: Off-white solid
• CAS Number: [1628208-23-0]
• Formula: C16H14N4O

Application Notes

• Application Notes: CPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1 CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells in vitro.2 KDM5 demethylases have recently been shown to repress the immune response to tumors via suppression of STING.3