GSK484 hydrochloride, CAS [[1652591-81-5]]

Product Overview

• Article Name: GSK484 hydrochloride, CAS [[1652591-81-5]]
• Biozol Catalog Number: FBM-10-4043
• Supplier Catalog Number: 10-4043
• Alternative Catalog Number: FBM-10-4043-5MG, FBM-10-4043-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: [(3S,4R)-3-Amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylbenzimidazol-5-yl]methanone hydrochloride

Product Description

PAD4 inhibitor

Product Properties

• Molecular Weight: 510.04
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1652591-81-5]
• Formula: C27H31N5O3HCl

Application Notes

• Application Notes: GSK484 is a potent (IC50 = 50 nM) and selective inhibitor of protein arginine deiminase (PAD4).1 It blocks neutrophil extracellular trap formation in human neutrophils.1,2 GSK484 abrogates thrombus formation on heparin-induced thrombocytopenia/thrombosis.3 It protected against reperfusion injury in both stroke4 and cardiac5 models. GSK484 attenuated tumor cell stemness in esophageal squamous cell carcinoma.6 It prevented surgery-induced tumor recurrence via inhibition of neutrophil extracellular trap-induced reprogramming of cancer cell metabolism.7