SR3335, CAS [[293753-05-6]]

Product Overview

• Article Name: SR3335, CAS [[293753-05-6]]
• Biozol Catalog Number: FBM-10-4068
• Supplier Catalog Number: 10-4068
• Alternative Catalog Number: FBM-10-4068-5MG, FBM-10-4068-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide. Alternate Names: ML176

Product Description

RORalpha partial inverse agonist

Product Properties

• Molecular Weight: 405.33
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [293753-05-6]
• Formula: C13H9F6NO3S2

Application Notes

• Application Notes: SR3335 (293753-05-6) is a selective RORalpha partial inverse agonist (IC50 = 480 nM) - displays no activity at RORß, RORgamma, or FXR.1 It was able to suppress gluconeogenesis in diet-induced obese mice. SR3335 was able to upregulate uncoupling protein 1 (UCP1), a unique mitochondrial protein devoted to thermogenesis, in wild type mice leading to decreased body weight and fat mass.2,3 It inhibited the development of mouse and human TH17 cells in vitro and in vivo leaving thymic T cells intact.4 SR3335s ability to block pathogenic, but not protective TH17 cell function makes it an important new tool in the study of TH17-mediated inflammatory and autoimmune diseases.