eFT508, CAS [[1849590-01-7]]

Product Overview

• Article Name: eFT508, CAS [[1849590-01-7]]
• Biozol Catalog Number: FBM-10-4081
• Supplier Catalog Number: 10-4081
• Alternative Catalog Number: FBM-10-4081-5MG, FBM-10-4081-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-[(6-Aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1-cyclohexane]-1,5-dione. Alternate Names: Tomivosertib

Product Description

Potent MNK1/2 inhibitor

Product Properties

• Molecular Weight: 340.39
• Purity: 98% by HPLC NMR (Conforms)
• Form: Pale yellow solid
• CAS Number: [1849590-01-7]
• Formula: C17H20N6O2

Application Notes

• Application Notes: eFT508 is a potent (IC50s = 2.4 nM MNK1, 1.0 nM MNK2) and highly selective inhibitor of the mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2), key regulators of mRNA translation protein eukaryotic initiation factor eIF4E.1 It potently inhibits phosphorylation of eIF4E in multiple solid and hematological tumor lines leading to blockade of pro-inflammatory and pro-tumorigenic cytokine production. eFT508 reversed the aggressive and metastatic characteristics of mouse liver cancer via inhibition of PD-L1 upregulation.2 Displays inhibitory effects in various cancers models including acute myeloid leukemia3, gastric4, and breast5. eFT-508 has also shown efficacy in treating neuropathic pain via the MNK-eIF4E pathway.6,7,8