Etrumadenant, CAS [[2239273-34-6]]

Product Overview

• Article Name: Etrumadenant, CAS [[2239273-34-6]]
• Biozol Catalog Number: FBM-10-4091
• Supplier Catalog Number: 10-4091
• Alternative Catalog Number: FBM-10-4091-5MG, FBM-10-4091-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-[2-Amino-6-[1-[[6-(2-hydroxypropan-2-yl)-2-pyridinyl]methyl]triazol-4-yl]pyrimidin-4-yl]-2-methylbenzonitrile. Alternate Names: AB928

Product Description

Dual A2AR/A2BR antagonist

Product Properties

• Molecular Weight: 426.48
• Purity: >98% by HPLC NMR (Conforms)
• Form: Tan solid
• CAS Number: [2239273-34-6]
• Formula: C23H22N8O

Application Notes

• Application Notes: Etrumadenant is a potent dual adenosine receptor antagonist (Ki: A2AR = 1.5 nM, A2BR = 2.0 nM)1.2 It blocked immunosuppressive signaling and increased cytokine secretion and proliferation in CAR T cells.3 Etrumadenant acted syntergistically with epirubicin and a nanomedicine formulation to reverse adenosine-mediated immunosuppression in a triple negative breast cancer model.4