Preladenant, CAS [[377727-87-2]]

Product Overview

• Article Name: Preladenant, CAS [[377727-87-2]]
• Biozol Catalog Number: FBM-10-4102
• Supplier Catalog Number: 10-4102
• Alternative Catalog Number: FBM-10-4102-5MG, FBM-10-4102-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine. Alternate Names: SCH 420814

Product Description

Adenosine A2A receptor antagonist

Product Properties

• Molecular Weight: 503.57
• Purity: >98% by HPLC NMR (Conforms)
• Form: Beige solid
• CAS Number: [377727-87-2]
• Formula: C25H29N9O3

Application Notes

• Application Notes: Preladenant is a potent (Ki = 1.1nM) and selective (>1000-fold over other adenosine receptors) adenosine A2A antagonist.1 It has shown efficacy in rodent and primate models of Parkinsons disease without inducing dyskinesias and displays antidepressant effects.1-3 It has been shown that activation of the adenosine A2A receptor blocks the activation of immune cells and increases the number of regulatory T-cells.4-6 Currently in clinical trials as combination therapy with pembrolizumab.7