Bempedoic acid, CAS [[738606-46-7]]

Product Overview

• Article Name: Bempedoic acid, CAS [[738606-46-7]]
• Biozol Catalog Number: FBM-10-4114
• Supplier Catalog Number: 10-4114
• Alternative Catalog Number: FBM-10-4114-10MG, FBM-10-4114-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid. Alternate Names: ESP 55016, ETC-1002

Product Description

ATP citrate lyase inhibitor

Product Properties

• Molecular Weight: 344.49
• Purity: >98% by TLC NMR (Conforms)
• Form: White solid
• CAS Number: [738606-46-7]
• Formula: C19H36O5

Application Notes

• Application Notes: Inhibitor of ATP citrate lyase (ACL) and activator of AMPK used in the treatment of hypercholesterolemia.1,2 In vivo, the active molecule is the CoA ester.2 Bempedoic acid requires activation by very long-chain acyl-CoA-synthetase (ACSVL1) - the absence of ACSVL1 in skeletal muscle provides a mechanistic basis for its use in statin-intolerant patients.3 LDL receptor upregulation, decreased LDL-C, and attenuation of atherosclerosis activities are independent of AMPK activation. It significantly cuts the risk of major cardiovascular events.4 Combination treatment of breast and pancreatic cancer cell lines with bempedoic acid and CDK4/6 inhibitors reduced cell growth and invasion.5 It displays anti-inflammatory activity possibly through both ACL inhibition6,7 and AMPK activation8.