Chemical Name: 2-[3-[4-(1H-Indazol-5-yl)amino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide. Alternate Names: KD025, SLx-2119
ROCK2 inhibitor
Molecular Weight:
452.52
Purity:
98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[911417-87-3]
Formula:
C26H24N6O2
Application Notes:
Belumosudil is a selective inhibitor of Rho kinase 2 (ROCK2) - IC50s: ROCK2 = 105 nM, ROCK1 = 24 µM in enzyme assays.1 It downregulated the ability of T cells to secrete IL-21 and IL-17, but not IFN-g, in response to T cell stimulation in vitro via a STAT3-dependent mechanism.2 Belumosudil ameliorated graft-versus-host disease in multiple models3,4 and was recently approved by the FDA for the treatment of GVHD (July 2021). It has also been shown to suppress adipogenesis.5-7 Suppression of adipocyte differentiation is mediated via casein kinase 2 inhibition (IC50 = 50 nM) and not ROCK2 inhibition.8
* VAT and and shipping costs not included. Errors and price changes excepted
