Gilteritinib, CAS [[1254053-43-4]]

Product Overview

• Article Name: Gilteritinib, CAS [[1254053-43-4]]
• Biozol Catalog Number: FBM-10-4170
• Supplier Catalog Number: 10-4170
• Alternative Catalog Number: FBM-10-4170-5MG, FBM-10-4170-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide. Alternate Names: ASP2215

Product Description

FLT3 inhibitor

Product Properties

• Molecular Weight: 552.72
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white to pale pink solid
• CAS Number: [1254053-43-4]
• Formula: C29H44N8O3

Application Notes

• Application Notes: Potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2