GSK2636771, CAS [[1372540-25-4]]

Product Overview

• Article Name: GSK2636771, CAS [[1372540-25-4]]
• Biozol Catalog Number: FBM-10-4172
• Supplier Catalog Number: 10-4172
• Alternative Catalog Number: FBM-10-4172-5MG, FBM-10-4172-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid

Product Description

Selective PI3Kß inhibitor

Product Properties

• Molecular Weight: 433.43
• Purity: >98% by HPLC NMR (Conforms)
• Form: Pale yellow solid
• CAS Number: [1372540-25-4]
• Formula: C22H22F3N3O3

Application Notes

• Application Notes: GSK2636771 is a potent, selective (>1000-fold over alpha, 10-fold over delta, and >2000-fold over gamma), and orally bioavailable inhibitor of PI3Kß (IC50 = 5.2 nM).1 Active in vitro against multiple types of PTEN-deficient cancer cells. GSK2636771 potently blocked migration and invasion of DU145 prostate cancer cells.2 GSK2636771 has also been identified as a GPR39 agonist.3