NE-100, CAS [[149409-57-4]]

Product Overview

• Article Name: NE-100, CAS [[149409-57-4]]
• Biozol Catalog Number: FBM-10-4200
• Supplier Catalog Number: 10-4200
• Alternative Catalog Number: FBM-10-4200-5MG, FBM-10-4200-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N,dipropylbenzeneethanamine hydrochloride

Product Description

Sigma-1 antagonist

Product Properties

• Molecular Weight: 391.97
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [149409-57-4]
• Formula: C23H33NO2HCl

Application Notes

• Application Notes: NE-100 is potent inhibitor of the sigma receptor () with selectivity for sigma-1 (IC50 = 1.5 nM) over sigma-2 (IC50 = 85 nM).1,2 NE-100 suppressed ischemia-induced neuronal cell death in mice via upregulation of GPR78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma 1 independent manner.3