Siramesine, CAS [[147817-50-3]]

Product Overview

• Article Name: Siramesine, CAS [[147817-50-3]]
• Biozol Catalog Number: FBM-10-4202
• Supplier Catalog Number: 10-4202
• Alternative Catalog Number: FBM-10-4202-5MG,FBM-10-4202-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Lu 28-179

Product Description

Sigma-2 agonist

Product Properties

• Molecular Weight: 454.59
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [147817-50-3]
• Formula: C30H31FN2O

Application Notes

• Application Notes: Siramesine (Lu 28-179) is a 2 selective agonist (IC50s: 1 = 17nM, 2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage.3,4,5 Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6