Chemical Name: N-(5-tert-Butyl-1H-pyrazol-3-yl)-2-[(3R)-3-propan-2-ylpiperazin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Spastin inhibitor
Molecular Weight:
382.52
Purity:
98% by HPLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[2351882-11-4]
Formula:
C20H30N8
Application Notes:
Spastazoline is an ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin. It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2). A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.
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