CGP-37157, CAS [[75450-34-9]]

Product Overview

• Article Name: CGP-37157, CAS [[75450-34-9]]
• Biozol Catalog Number: FBM-10-4250
• Supplier Catalog Number: 10-4250
• Alternative Catalog Number: FBM-10-4250-10MG, FBM-10-4250-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Product Description

MPTP inhibitor

Product Properties

• Molecular Weight: 324.22
• Purity: 99% by TLC
• Form: White solid
• CAS Number: [75450-34-9]
• Formula: C15H11Cl2NOS

Application Notes

• Application Notes: Inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 µM.1 Does not inhibit the plasmalemmal NCX.2 Also inhibits voltage-gated Ca2+ channels in intact cells and therefore its use in cellular studies must employ adequate controls.3 Prevents sudden death in a Guinea pig model of heart failure.4 Displays pronounced cytoprotective effects in chromaffin cells5 and in neuronal injury models.6 Blood-brain barrier permeant.