PF-4136309, CAS [[1341224-83-6]]

Product Overview

• Article Name: PF-4136309, CAS [[1341224-83-6]]
• Biozol Catalog Number: FBM-10-4261
• Supplier Catalog Number: 10-4261
• Alternative Catalog Number: FBM-10-4261-5MG, FBM-10-4261-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide. Alternate Names: INCB8761

Product Description

CCR2 antagonist

Product Properties

• Molecular Weight: 568.60
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1341224-83-6]
• Formula: C29H31F3N6O3

Application Notes

• Application Notes: PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2.1 PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer.2 In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study.3