Chemical Name: 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridine-1-one
BRD9 bromodomain inhibitor
Molecular Weight:
353.42
Purity:
>98% by HPLC, NMR (Conforms)
Form:
White solid
CAS Number:
[1883429-22-8]
Formula:
C20H23N3O3
Application Notes:
Potent, selective, and cell permeable inhibitor of the BRD9 bromodomain, a subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex (IC50 = 75 nM).1 It displayed antitumor activity in an acute myeloid leukemia xenograft model. BI-9564 displayed cytotoxic and anti-proliferative effects in 5 rhabdoid tumor cell lines.2
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