Chemical Name: [(4S)-4-[(3aS,4S,7aR)-4-Hydroxy-6-methyl-3-methylidene-2-oxo-3a,4,7,7a-tetrahydro-1-benzofuran-5-yl]pentyl] acetate
Anti-neuroinflammatory agent
Molecular Weight:
308.37
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[33627-41-7]
Formula:
C17H24O5
Application Notes:
1-O-Acetylbritannilactone is a natural product with anti-inflammatory and anti-allergic properties that is extracted from the flowers of Inula japonica and Inula britannica.1,2 It inhibits angiogenesis and lung cancer cell growth via regulation of VEGF signaling.3,4 1-O-acetylbritannilactone suppressed microglial activation by regulating inflammation and autophagy to ameliorate LPS-mediated neuroinflammation via targeting of PDZ binding kinase (PBK).5
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