Chemical Name: 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride. Alternate Names: KB-2796
Calcium channel blocker
Molecular Weight:
541.46
Purity:
>98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[101477-54-7]
Formula:
C27H30F2N2O32HCl
Application Notes:
Lomerizine is a clinically useful calcium channel blocker (L and T-type). It is used for the treatment of migraine headaches, however its antimigraine effects are believed to be due to its 5HT2A antagonistic effects.1 Lomerizine also displays anti-glaucoma effects via an increase in ocular circulation and protection of neuronal cells against retinal neurotoxicity with minimal cardiovascular effects.2 Lomerizine has also shown various other neuroprotective properties.3,4,5,6
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