Sotrastaurin, CAS [[425637-18-9]]

Product Overview

• Article Name: Sotrastaurin, CAS [[425637-18-9]]
• Biozol Catalog Number: FBM-10-4350
• Supplier Catalog Number: 10-4350
• Alternative Catalog Number: FBM-10-4350-5MG, FBM-10-4350-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione. Alternate Names: AEB071

Product Description

Pan-PKC inhibitor

Product Properties

• Molecular Weight: 438.49
• Purity: >98% by HPLC NMR (Conforms)
• Form: Orange solid
• CAS Number: [425637-18-9]
• Formula: C25H22N6O2

Application Notes

• Application Notes: Sotrastaurin is a highly selective and potent (IC50s for PKC isotypes: alpha = 2.1 nM, ß1 = 2.0 nM, delta = 1.3 nM, epsilon = 6.2 nM, eta = 6.1 nM, T = 1.0 nM) pan-PKC inhibitor.1 Potent immunomodulatory agent that inhibits early T-cell activation and displays potential for the prevention of transplant rejection and the treatment of inflammatory diseases.2,3 Sotrastaurin has anticancer activity in various cancer models including breast4, CLL5, ocular melanoma6, and B-cell lymphoma7.