Nerandomilast, CAS [[1423719-30-5]]

Product Overview

• Article Name: Nerandomilast, CAS [[1423719-30-5]]
• Biozol Catalog Number: FBM-10-4391
• Supplier Catalog Number: 10-4391
• Alternative Catalog Number: FBM-10-4391-5MG, FBM-10-4391-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: [1-[[(5R)-2-[4-(5-Chloropyrimidin-2-yl)piperidin-1-yl]-5-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]amino]cyclobutyl]methanol. Alternate Names: BI 1015550

Product Description

PDE4B inhibitor

Product Properties

• Molecular Weight: 448.97
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1423719-30-5]
• Formula: C20H25ClN6O2S

Application Notes

• Application Notes: Nerandomilast is a potent and selective inhibitor of phosphodiesterase 4B (IC50s: PDE4A = 248 nM, PDE4B = 10 nM, PDE4C = 8,700 nM, PDE4D = 91 nM, PDE7A = 14 µM, PDE3A = 120 µM, PDE1C = 46 µM).1 It inhibited TNFalpha release (IC50 = 35 nM) and IL-2 release (IC50 = 9 nM) in human PBMCs. Nerandomilast has potent anti-inflammatory activity and displayed efficacy in mouse models of lung fibrosis.1,2 Approved for the treatment of idiopathic pulmonary fibrosis.