ZT-1a, CAS [[212135-62-1]]

Product Overview

• Article Name: ZT-1a, CAS [[212135-62-1]]
• Biozol Catalog Number: FBM-10-4402
• Supplier Catalog Number: 10-4402
• Alternative Catalog Number: FBM-10-4402-5MG, FBM-10-4402-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 5-Chloro-N-[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxybenzamide

Product Description

SPAK kinase inhibitor

Product Properties

• Molecular Weight: 445.72
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [212135-62-1]
• Formula: C22H15Cl3N2O2

Application Notes

• Application Notes: ZT-1a is a non-ATP competitive inhibitor (IC50 = 44.3 µM 0.01 mM ATP) of SPAK kinase (STK39), a master regulator of cation-Cl- cotransporters.1 It attenuated cerebral edema, protected against ischemic brain damage, and improved post-ischemic neurological outcomes in mouse models of stroke.1,2 ZT-1a showed neuroprotective effects in mouse models of vascular dementia3 and multiple sclerosis4. It inhibited the progression of hepatocellular carcinoma in rodent models and showed synergistic effects with PD-1 antibodies by helping to prevent tumor microenvironment immune exhaustion.5