Chemical Name: N-Methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide. Alternate Names: BAY 57-1293
HSV helicase-primase inhibitor
Molecular Weight:
402.49
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[348086-71-5]
Formula:
C18H18N4O3S2
Application Notes:
Pritelivir is a potent non-nucleosidic inhibitor of the herpes simplex virus helicase-primase (IC50 = 20 nM HSV1/2).1 Active against acyclovir-resistant HSV. Pritelivir showed superior efficacy against HSV in vivo compared to acyclovir, famiciclovir, ganciclovir, and valacyclovir.2 It greatly reduced the formation of ß-amyloid and abnormal tau in HSV1 infected cultured cells.3
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