Pritelivir is a potent non-nucleosidic inhibitor of the herpes simplex virus helicase-primase (IC50 = 20 nM HSV1/2).1 Active against acyclovir-resistant HSV. Pritelivir showed superior efficacy against HSV in vivo compared to acyclovir, famiciclovir, ganciclovir, and valacyclovir.2 It greatly reduced the formation of ß-amyloid and abnormal tau in HSV1 infected cultured cells.3
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