GLPG3970, CAS [[2403733-82-2]]

Product Overview

• Article Name: GLPG3970, CAS [[2403733-82-2]]
• Biozol Catalog Number: FBM-10-4446
• Supplier Catalog Number: 10-4446
• Alternative Catalog Number: FBM-10-4446-5MG, FBM-10-4446-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 8-Methoxy-6-[7-(2-morpholin-4-ylethoxy)imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one

Product Description

SIK2/3 inhibitor

Product Properties

• Molecular Weight: 504.51
• Purity: >98% by HPLC NMR (conforms)
• Form: Off-white solid
• CAS Number: [2403733-82-2]
• Formula: C25H27F3N4O4

Application Notes

• Application Notes: GLPG3970 is a potent and selective (against a panel of 372 kinases) SIK2/3 inhibitor (IC50s: SIK2 = 7.8 nM, SIK3 = 3.8 nM).1 It reduced THFalpha and increased IL-10 levels in an LPS challenge model in mice and displayed efficacy in a mouse model of colitis. GLPG3970 promoted reprogramming of human myeloid cells toward an anti-inflammatory phenotype, reprogrammed monocyte-dendritic differentiation toward stable tolerogenic phenotypes, and suppressed T-cell activation.2 It also displayed efficacy in mouse models of psoriasis and arthritis.