Chemical Name: 3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one. Alternate Names: STA-9090
HSP90 inhibitor
Molecular Weight:
364.40
Purity:
98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[888216-25-9]
Formula:
C20H20N4O3
Application Notes:
Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells, 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site.1 It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50s between 14 and 280 nM.2 Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes.3 In multiple clinical trials for various cancers.
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