Chemical Name: N-[4-[4-(Cyclopropylmethyl)piperazine-1-carbonyl]phenyl]quinoline-8-sulfonamide. Alternate Names: AG-348
Pyruvate kinase activator
Molecular Weight:
450.56
Purity:
99% by HPLC NMR (Conforms)
Form:
Beige solid
CAS Number:
[1260075-17-9]
Formula:
C24H26N4O3S
Application Notes:
Potent (AC50 = 29 nM PKR, 37 nM PKM2, 33 nM PKL) allosteric activator of pyruvate kinase.1 In clinical use for the treatment of hemolytic anemia2 and a potential agent for the treatment for ß-thalassemia3 and sickle cell anemia4.
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