GS-441524, CAS [[1191237-69-0]]

Product Overview

• Article Name: GS-441524, CAS [[1191237-69-0]]
• Biozol Catalog Number: FBM-10-4485
• Supplier Catalog Number: 10-4485
• Alternative Catalog Number: FBM-10-4485-10MG, FBM-10-4485-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

Product Description

Remdesivir active metabolite

Product Properties

• Molecular Weight: 291.27
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1191237-69-0]
• Formula: C12H13N5O4

Application Notes

• Application Notes: Parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir. Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolyzed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs.