PNU 282987 is a selective alpha7 nicotinic acetylcholine receptor (nAChR) agonist (Ki = 26 nM).1 The alpha7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimers, Parkinsons, schizophrenia, and attention deficit disorders - agonism of this receptor with PNU 282987 has shown potential to ameliorate these deficits.2-5
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