Chemical Name: 1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea
FGFR inhibitor
Molecular Weight:
523.67
Purity:
99% by HPLC, NMR (Conforms)
Form:
Yellow solid
CAS Number:
[219580-11-7]
Formula:
C28H41N7O3
Application Notes:
Inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR promotes stem sell self renewal.2,3
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