SAG, CAS [[364590-63-6]]

Product Overview

• Article Name: SAG, CAS [[364590-63-6]]
• Biozol Catalog Number: FBM-10-4525
• Supplier Catalog Number: 10-4525
• Alternative Catalog Number: FBM-10-4525-1MG, FBM-10-4525-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiiophene-2-carboxamide dihydrochloride. Alternate Names: Smoothened Agonist

Product Description

Smoothened agonist

Product Properties

• Molecular Weight: 490.07
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [364590-63-6]
• Formula: C28H28ClN3OS

Application Notes

• Application Notes: Smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine. The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 µM (EC50 for SMO activation is ~ 3 nM).1