20(S)-Hydroxycholesterol, CAS [[516-72-3]]

Product Overview

• Article Name: 20(S)-Hydroxycholesterol, CAS [[516-72-3]]
• Biozol Catalog Number: FBM-10-4540
• Supplier Catalog Number: 10-4540
• Alternative Catalog Number: FBM-10-4540-1MG,FBM-10-4540-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Smoothened activator

Product Properties

• Molecular Weight: 402.66
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [516-72-3]
• Formula: C27H46O2

Application Notes

• Application Notes: 20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5