Chemical Name: Thenoyltrifluoroacetone, 4,4,4-Trifluoro-1-(2-thienyl)-1,3-butanedione
Mitochondrial Complex II inhibitor
Molecular Weight:
222.18
Purity:
>98%, NMR (Conforms)
Form:
Pale yellow solid
CAS Number:
[326-91-0]
Formula:
C8H5F3O2S
Application Notes:
TTFA blocks the respiratory chain complex II causing inhibition of mitochondrial respiration. Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp and Qd.1 Inhibition of Complex II by TFA has been shown to cause a delay in overall cell cycle progression leading to oxidative stress.2,3 TTFA also was found to inhibit porcine liver carboxylesterase (IC50 = 0.54 µM).4
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