AGI-5198, CAS [[1355326-35-0]]

Product Overview

• Article Name: AGI-5198, CAS [[1355326-35-0]]
• Biozol Catalog Number: FBM-10-4599
• Supplier Catalog Number: 10-4599
• Alternative Catalog Number: FBM-10-4599-5MG, FBM-10-4599-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide

Product Description

R132 mutant isocitrate dehydrogenase inhibitor

Product Properties

• Molecular Weight: 462.56
• Purity: 98% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1355326-35-0]
• Formula: C27H31FN4O2

Application Notes

• Application Notes: AGI-5198 is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1 It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2 This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) form alpha-ketoglutarate (2-OG).