Piperine is a natural product isolated from black pepper that has myriad biological effects. Piperine has recently been shown to increase the metabolic rate of resting muscle (fast twitch skeletal fibers) without effecting slow twitch or cardiac fibers via destabilization of the super-relaxed state of myosin heads.1 This is proposed as a mechanism for the mitigation of obesity and type 2 diabetes by piperine. Piperine is an agonist at the TRPV1 receptor (EC50 = 38 µM).2 Piperine has various effects on drug metabolism3, inhibits human P-glycoprotein and CYP3A44 as well as UDP-glucose dehydrogenase and glucuronidation5
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