Chemical Name: N-Benzyl-N-hydroxy-2,2-dimethylbutanamide
RIP1 kinase inhibitor
Molecular Weight:
221.30
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[1956370-21-0]
Formula:
C13H19NO2
Application Notes:
RIPA-56 is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM.
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