Chemical Name: (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]napthyridin-10-one. Alternate Names: Matridin-15-one
Induces RIP3-dependent necroptosis
Molecular Weight:
248.36
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[519-02-8]
Formula:
C15H24N2O
Application Notes:
Matrine is a natural product found in the plant Sophora flavescens. It has been found to possess myriad biological activities including a positive inotropic effect1,2, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP723, various anti-cancer effects4,5,6. Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.7
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